MERASYN GELMERASYN GEL
(and dosage form):
Each 5 mL:
|Aluminium Hydroxide Dried Gel||200 mg|
|Magnesium Hydroxide||200 mg|
Benzyl alcohol 0,3% v/v, Methylparaben 0,09% m/v, Propylparaben 0,012% m/v, Butylparaben 0,012% m/v (added as preservatives).
A. 11.4 Antacids.
Both aluminium hydroxide and magnesium hydroxide reduce hyperacidity. Magnesium hydroxide has a rapid and aluminium hydroxide a prolonged antacid action. Peptic activity is inhibited through both antacids by causing elevation of the gastric pH. Aluminium hydroxide has a direct antipeptic action as well as a demulcent effect which helps protect the gastrointestinal mucosa and in this way prevents further irritation or erosion and so permits healing. Aluminium hydroxide has a mild constipating effect and magnesium hydroxide a mild laxative action; because of this balanced effect there is virtually no constipation or diarrhoea. Both antacids are non-systemic and there is virtually no risk of alkalosis developing.
Methycellulose has a demulcent action and helps protect gastrointestinal mucosa. Simethicone aids in the dispersion and inhibits formation of “mucus-surrounded” gas bubbles in the gastrointestinal tract. This anti-foam action is exerted by changing the surface tension of the gas bubbles so that they coalesce. This permits escape of trapped gas, which then can be eliminated through belching or though passing flatus via the rectum. Simethicone has been widely investigated and used. It has a rapid action and is non-toxic. Being physiologically inert, it has no effect on digestion and is not absorbed through the gastrointestinal mucosa. Infants have been shown to tolerate simethicone well.
By dispersing gas bubble with the anti-flatulent, contact with the gastric antacid is facilitated. Coverage of the mucosa by the antacid and demulcent agents is also improved.
Gastric distress resulting from retention of gas and hyperacidity such as may occur in functional dyspepsia. The latter may result from dietary indiscretions, air swallowing, excessive smoking, constipation or altered gastric motor activity.
Gastric hyperactivity, gastritis (including iatrogenic gastritis), heartburn of pregnancy, oesophagitis.
Adjunctively, in peptic ulcer and hiatus hernia.
SIDE-EFFECTS AND SPECIAL PRECAUTIONS:
Aluminium may cause nausea, vomiting and constipation. Large doses can cause intestinal obstruction. Excessive or normal doses in patients with low phosphate diets may cause phosphate depletion accompanied by increased resorption and urinary excretion of calcium with the risk of osteomalacia. Osteomalacia, with chronic renal failure on high aluminium dose as a phosphatebinding agent.
Magnesium may cause diarrhoea. Hypermagnesaemia may occur if renal function is impaired. Magnesium hydroxide and other magnesium salts, in the presence of renal insufficiency, may cause central nervous system depression.
Aluminium and magnesium may alter the absorption of other medicines from the gastro-intestinal tract if administered concomitantly.
200 mL and 350 mL amber glass bottles.
Store below 25°C. Keep out of reach of children.
Protect from light.